I've now fully changed motherboard and CPU and the issue persists through multiple different USB ports. It seems to be several different problems.
Occasionally even from a fresh boot the beadapanel 5c will be unresponsive. It won't have the blue light flashing and the backlight won't come on. This causes aida64 to be completely unresponsive until it's unplugged. A similar issue happens when resuming from sleep, the panel won't be recognized by the online tool and aida64 reports it as a usb init error. Completely unsure of what to do, restarting aida64 doesn't work (sometimes it's required even when the panel is functioning correctly) and I've now tried a total of 4 different direct motherboard usbs (2 on each mobo), 3 different usb hub ports, four different usb cables and I'm still forced to unplug and replug (sometimes more than once) to get the panel to function. I'm starting to think the panel itself is defective in some capacity but I have no way to know this.