Phew, I am glad I am not the only one with this issue!  
	Specs: 
	MSI X570-A Pro 
	Ryzen5 3600 
	Arctic Freezer II 240 
	16Gb 3000mhz DDR4 
	WD 1Tb M.2 SSD 
	EVGA 2060 Super SC 
	Running a 32" QHD (Main), a 27" QHD (side panel), plus a 5" 800x400 Pi Monitor inside my case with the AIDA64 SensorPanel on (with a nice background of my wedding pic, 50% Transparency seems better in reality than in the pic, sorry).  
	Same issue of Right Click on my Desktop and my Menu would vanish before I could click anything, same if I clicked on a Folder, Recycle Bin etc. 
	My set up with SensorPanel was: 
	Always on top, 
	Prevent from being Minimized, 
	Lock Position, 
	Lock Size, 
	Enable Context Menu.  
	Disabling the "Always on top" feature solved it immediately! 
	Re enable "Always on Top" - lose my Right Click again. 
	Disable "Always on Top" - solved again.  
	Definitely a correlation.