My computer has also recently had a similar problem. I have OSD monitoring on my secondary monitor. When running games, every time the OSD refreshes, it causes the game to stutter once. My specific configuration is:
I7 8700K 4x8G DDR4 3600
RX6750GRE 12G P106-100 dual graphics cards
The hard drive is a Kioxia M.2 SSD
I disabled the following in the stability options of AIDA64:
Low-level sensor operations
Then the other options are basically the default ones, and this way there won't be any stuttering.
AIDA64 Ex v7.50.7200