Make sure you are using the latest Prolific drivers for the TMS, ver 3.3.11.152 dated 3/12/2010. Once you have it working and can identify which COM port it uses, try setting the COM port to "Fixed" in the Settings window for the TMS program. Are you using a motherboard USB header for your TMS or are you plugging it in to an external USB port?
You also should run Aida 1.6