When "Show OSD panel" is enabled, audio output exhibits clicks and pops intermittently, but appears to be multiple of 5 seconds.
With USB audio (DAC), the frequency is ~ once every 30 seconds. From headphone jack, it ~ once every 1 to 3 minutes.
It occurs when playing music from iTunes or VLC.
A simple way to notice this is to play a test tone, e.g., 1-KHz tone from a test CD.
So far, it's reproducible on multiple Dell laptops, latitude e6430 (i5-3340M), latitude e6410 (i7-640M) and vostro 1400 (T7250).
OS - Win 10 Pro (RTM - Build 10240)